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> 【DLL3】
DLL3信息
英文名称：Delta-like protein 3
中文名称：δ样蛋白-3
靶点别称：Delta-Like Protein 3，Delta3，Delta-Like 3，Drosophila Delta Homolog 3，SCDO1，Delta-Like 3 (Drosophila)，DLL3，Delta (Drosophila)-Like 3，Delta Like Canonical Notch Ligand 3
中文名称：δ样蛋白-3
靶点别称：Delta-Like Protein 3，Delta3，Delta-Like 3，Drosophila Delta Homolog 3，SCDO1，Delta-Like 3 (Drosophila)，DLL3，Delta (Drosophila)-Like 3，Delta Like Canonical Notch Ligand 3
上市药物数量：0
临床药物数量：4
最高研发阶段：临床二期
临床药物数量：4
最高研发阶段：临床二期
DLL3dexiconelektrik.com列表
属性
| 货号 | 物种 | dexiconelektrik.com描述 | 蛋白结构 | 纯度 | 活性 |
|---|---|---|---|---|---|
| DL3-H5255 |
 Human |
Human DLL3 Protein, Fc Tag (MALS verified) |
 |
  |
  |
| DL3-H52H4 |
Human |
Human DLL3 Protein, His Tag (MALS verified) |
 |
 |
 |
| DL3-C52H3 |
 Cynomolgus |
Cynomolgus DLL3 Protein, His Tag |
 |
 |
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| DL3-HF253 |
Human |
FITC-Labeled Human DLL3 Protein, Fc Tag |
 |
 |
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| DL3-HF2H4 |
Human |
FITC-Labeled Human DLL3 Protein, His Tag |
 |
 |
 |
| DL3-R52H3 |
 Rat |
Rat DLL3 Protein, His Tag |
 |
 |
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| DL3-R52H4 |
 Rhesus macaque |
Rhesus macaque DLL3 Protein, His Tag |
 |
 |
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| DL3-H82E4 |
Human |
Biotinylated Human DLL3 Protein, His,Avitag™ (MALS verified) |
 |
 |
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| DL3-H82F5 |
Human |
Biotinylated Human DLL3 Protein, Fc,Avitag™ |
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||
| DL3-H52Ha |
Human |
Human DLL3 (353-492) Protein, His Tag |
 |
 |
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| DL3-H52Hy |
Human |
Human DLL3 (176-492) Protein, His Tag |
 |
 |
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| DL3-H52Hz |
Human |
Human DLL3 (312-492) Protein, His Tag |
 |
 |
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| DL3-M52H9 |
 Mouse |
Mouse DLL3 Protein, His Tag |
 |
 |
|
| DL3-C52H9 |
Cynomolgus |
Cynomolgus DLL3 (27-488) Protein, His Tag |
 |
 |
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评论(4)
DL3-H5255|Human DLL3 Protein, Fc Tag (MALS verified)
- 132XXXXXXX8
- 前期申请了蛋白和相应的抗体试用装进行了活性鉴定，显示很好的结合活性，故大批量订购开展小鼠免疫。
-
> - 2021-12-25
18人赞
DL3-H52H4|Human DLL3 Protein, His Tag (MALS verified)
- 132XXXXXXX8
- 该蛋白前期验证时发现有很好的结合活性，将包被浓度降低后仍较稳定的Emax，后期正式筛选过程中也是一如既往的稳定，内部尝试发现还是Acro的蛋白优秀。
-
> - 2021-12-25
14人赞
DL3-H52H4|Human DLL3 Protein, His Tag (MALS verified)
- 132XXXXXXX8
- 本dexiconelektrik.com一直用于高通量筛选，直接包被的浓度可将至0.5ug/ml，Emax可稳定在2.5~3，使用专利抗体与之结合的EC50也验证了其活性良好和稳定。
- 2021-12-25
1人赞
DLL3 分子别名
Delta3,delta-like 3 (Drosophila),delta-like protein 3,DLL3,Pudgy,SCDO1,SCDO1delta3
DLL3 分子背景
Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands.May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm. DLL3 protein is expressed on the surface of tumor cells but not in normal adult tissues.
DLL3 前沿进展
DLL3临床药物信息
| 英文名称 | 研发代码 | 研发阶段 | 公司 | 适应症 | 临床试验 |
|---|---|---|---|---|---|
| 89Zr-DFO-SC16.56 | 89Zr-DFO-SC16.56 | 临床一期 | Memorial Sloan Kettering Cancer Center | 小细胞肺癌 | 详情 |
| HPN-328 | HPN-328 | 临床二期 | Harpoon Therapeutics | 小细胞肺癌 | 详情 |
| Tarlatamab | AMG-757 | 临床二期 | 安进 | 小细胞肺癌, 前列腺癌 | 详情 |
| Rovalpituzumab tesirine | SC0001SCX; SC16LD6.5; SC0001-SCX; SC-0002; P256HB60FF | 临床一期 | 艾伯维, Stemcentrx | 实体瘤, 小细胞肺癌, 胶质母细胞瘤, 甲状腺髓样癌, 前列腺癌, 神经内分泌癌, 黑色素瘤 | 详情 |
